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3 edition of Formation of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, MX, by chlorination of aromatic model compounds and of fractions of humic water found in the catalog.

Formation of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, MX, by chlorination of aromatic model compounds and of fractions of humic water

Vivi-Ann LaМЉngvik

Formation of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, MX, by chlorination of aromatic model compounds and of fractions of humic water

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Published by Åbo Akademi University Press in Åbo .
Written in English

    Subjects:
  • Water -- Purification -- Chlorination -- By-products.,
  • Mutagens.

  • Edition Notes

    Includes bibliographical references (p. 48-54).

    Statementby Vivi-Ann Långvik.
    SeriesActa academiaie aboensis. Ser. B, Mathematica et physica = Matematik, Naturvetenskaper, Teknik,, vol. 54 nr 1, Acta Academiae Aboensis., v. 54, nr. 1
    Classifications
    LC ClassificationsAS262 .A35 vol. 54 nr. 1, TD462 .A35 vol. 54 nr. 1
    The Physical Object
    Pagination54 p. :
    Number of Pages54
    ID Numbers
    Open LibraryOL915906M
    ISBN 109529616430
    LC Control Number95212317

    Mutagens, teratogens and carcinogens are similar in that each causes some form of mutation. Congenital malformations can be caused by mutations, which may occur in the parent germ cell (sperm or ovum), in the resulting embryo (mutagenic effect), or in some cells of a fetus after development has begun (teratogenic effect). Read this book on Questia. Chemical Consequences: Environmental Mutagens, Scientist Activism, and the Rise of Genetic Toxicology by Scott Frickel, | Online Research Library: Questia Read the full-text online edition of Chemical Consequences: Environmental Mutagens, Scientist Activism, and the Rise of Genetic Toxicology (). Chlorinated drinking waters produced from humus-rich waters often have a high content of halogenated organic by-products which increases the mutagenicity of drinking water. With in vitro chlorination experiments we studied the formation of chloroform (CHCl 3) and mutagenicity of artificially recharged ground water samples. The water samples where obtained from an artificial ground water plant. Determination of the strong mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone in chlorinated drinking and humic water. Mutagenicity and genotoxicity of water treated for human consumption induced by chlorination by-products.


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Formation of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, MX, by chlorination of aromatic model compounds and of fractions of humic water by Vivi-Ann LaМЉngvik Download PDF EPUB FB2

Factors on the formation of strong mutagen [3-chloro(dichloromethyl)hydroxy-2(5H)-furanone] MX by chlorination of syringaldehyde Author links open overlay panel Yang Chengyong 1 Chen Zhuo 1 Zou Huixian 1 Lu Junhe 1 Zhang Jinqi 2Cited by: 7.

About % of the dissolved organic carbons were recovered from the lake water sample. After chlorine treatment of the Formation of the strong mutagen 3-chloro-4- book [3-chloro(dichloromethyl)hydroxy-2(5H)-furanone], MX was Formation of the strong mutagen 3-chloro-4- book with GCMS in the selected ion monitoring by: The strong mutagen, [3-chloro(dichloromethyl)hydroxy- 2(5H)-furanone] MX, was found to be one of the most potent mutagens in drinking water.

In this study, Formation of the strong mutagen 3-chloro-4- book organic matters from river water and lake water were separated into several compound classes by sorbtion on a series of resin by:   3-chloro(dichloromethyl)hydroxy-2(5 H)-furanone (MX), which was found to be a mutagen in bacteria and mammalian cells (Holmbom et al.,Jansson and Hyttinen, ), and to be a potent carcinogen in rats (Komulainen et al., ), is formed during chlorine disinfection of drinking water (Hemming et al., ).Cited by: Formation of AMES mutagenicity and of the strong bacterial mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water Authors: Backlund, Peter ; Kronberg, Leif ; Tikkanen, Leena.

The strong bacterial mutagen, 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some chlorinated phenolic compounds with structures related to aromatic units in aquatic humus.

Chlorination at pH 2 produced more Formation of the strong mutagen 3-chloro-4- book than chlorination at pH 7. Compounds structurally related to MX were also by: Identification of the strong mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone and of its geometric isomer Echloro(dichloromethyl)oxo-butenoic acid in mutagenic fractions of chlorine treated humic water and in drinking water.

6th Conference on Water Chlorination, Oak Ridge, by: 6. The strong mutagen, [3-chloro (dichloromethyl)hydroxy-2 (5H)-furanone] (MX) was found to occur in chlorinated drinking water in China. Some tap water samples from Jiangsu province, which contained MX of ng/L, Cited by: Humic water was treated with different disinfectants and examined for mutagenicity, 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX), Echl Cited by: Influence of chlorination pH and chlorine dose on the formation of mutagenic activity and the strong bacterial mutagen 3-chloro(dichloromethyl)hydroxy-5(2H)-furanone (MX) in water.

Chemosphere18 (), Cited by: The strong bacterial mutagen, 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) was formed by aqueous chlorination of some Formation of the strong mutagen 3-chloro-4- book phenolic compounds with structures related to.

Chlorination of the studied phenols resulted in Ames-mutagenicity and the formation of the mutagens MX and EMX. The molar ratios of MX to EMX varied from about 30–50 for caffeic acid and L-DOPA and from about to 2 for homovanillic acid, vanillin and : Vivi-Ann Långvik, Osmo Hormi, Leif Kronberg, Leena Tikkanen, Bjarne Holmbom.

The formation of the potent bacterial mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) and mutagenic activity were favoured by acidic chlorination conditions and high chlorine doses. Chlorinated humic waters from different locations differed slightly in the level of mutagenicity as well as in the proportion of activity derived from : Peter Backlund, Erik Wondergem, Leif Kronberg.

Formation and characterization of bacterial mutagens from reaction of the alternative disinfectant monochloramine with model aqueous solutions of fulvic acid in the earliest‐eluting (most polar) fraction.

The mutagenic by‐products appeared to be qualitatively similar to 3‐chloro‐4‐dichlorome‐thyl‐5‐hydroxy‐2‐(5H Cited by: 9. Influence of chlorination pH and chlorine dose on the formation of mutagenic activity and the strong bacterial mutagen 3-chloro(dichloromethyl)hydroxy-5(2H) Cited by: The strong Ames test mutagen 3-chloro(dichloromethyl)hydroxy(5H)-furanone (MX) was found to occur in chlorinated drinking and humic waters in sub μg L−1 concentrations.

Factors on the formation of strong mutagen [3-chloro(dichloromethyl)hydroxy-2(5H)-furanone] MX by chlorination of syringaldehyde. Water Research34 (17), DOI: /S(00) Ann‐Sofie Allard, Per‐Åke Hynning, Mikael Remberger, Alasdair H. by: 3-Chloro(chloromethyl)hydroxy-2(5H)-furanone (CMCF) is a strong direct acting bacterial mutagen found in chlorine-disinfected drinking water.

We studied the reaction of CMCF with 2‘-deoxyadenosine in buffered aqueous solutions and found that three main adducts were formed. The adducts were isolated and purified by C18 column chromatography and HPLC, and characterized on the basis of Cited by: 6. Chlorination of lignin and humic material in water produces the strong bacterical mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-fura-none or its acyclic form Zchloro(dichloromethyl)oxo-butenoic acid (“MX”), and its geometric E-isomer (“E-MX”).Cited by: 2.

Formation and properties of the mutagens 3-chloro(dichloromethyl)hydroxyl-2(5H)-furanone, a potent mutagen in chlorinated waters Holmbom In vitro studies of the biological effects of cigarette smoke by: 5. Start studying Chapter 8. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

Search. A mutagen that causes the formation of highly reactive ions. Base pair mutagen. A mutagen that alters adenine so that it base pairs with cytosine. Frame Shift Mutagen. Influence of chlorination pH and chlorine dose on the formation of mutagenic activity and the strong bacterial mutagen 3-chloro(dichloromethyl)hydroxy-5(2H)-furanone (MX) in water.

Studies on the potent bacterial mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone: aqueous stability, XAD recovery and analytical determination in drinking water and in chlorinated humic acid solutions. The determination of strong mutagen, 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone, in drinking water in Japan.

Haataja L, Vartiainen T, Lampelo S, Lötjönen S, Tuomisto J. Binding of the strong bacterial mutagen, 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) to bovine serum albumin. Toxicol Lett. Dec; 59 ()– Pukkala E, Teppo L.

Socioeconomic status and education as risk determinants of gastrointestinal cancer. There is limited information on the prevalence of the potent mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) in U.S.

water supplies. We measured MX concentrations and mutagenic activity in tap water samples from 36 surface water systems throughout by: Chen ZHUO of Shanghai Jiao Tong University, Shanghai (SJTU) | Read 3 publications | Contact Chen ZHUO Factors on the formation of strong mutagen [3-chloro(dichloromethyl)hydroxy-2(5H.

DeepDyve is the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. DeepDyve is the easiest way to get instant access to the academic journals you need.

A simple, selective and sensitive method for the analysis of the strong mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone (MX) and its brominated analogues (BMXs) in chlorine-treated water has been by: 2. Kronberg, L., B. Holmbom, and L. Tikkanen () Identification of the strong mutagen 3-chloro(dichloromethyl)hydroxy-2(5 H)-furanone and of its geometric isomer (E)chloro(dichloromethyl)oxobutenoic acid in mutagenic fractions of chlorine-treated humic water and in drinking by: 1.

Backlund P, Kronberg L and Tikkanen L () Formation of AMES mutagenicity and of the strong bacterial mutagen 3-chloro(dichloromethyl)hydroxy-2(5H)-furanone and other halogenated compounds during disinfection of humic water, Chemosphere, /(88),(), Online publication date: 1-JanCited by: Factors on the formation of strong mutagen [3-chloro(dichloromethyl)hydroxy-2(5H)-furanone] MX by chlorination of syringaldehyde.

Article. Dec ;Occupation: Professor. The effect of the organosulfur compounds, l-cysteine, l-cystine, reduced glutathione, deoxyalliin, and N-acetyl-l-cysteine, on mutagen formation in a meat model system was examined.

Samples containing glucose, glycine, and creatinine were heated in a diethylene glycol reflux system at °C in the presence or absence of organosulfur by: 8.

Book Review Carcinogens and mutagens in the environment. “Carcinogens and Mutagens in the Environment, volume II: Naturally Occurring Compounds: Endogenous Formation and Author: James M.

Gentile. Mutagen X (MX), or 3-chloro(dichloromethyl)hydroxy-5H-furanone, is a byproduct of the disinfection of water by is produced by reaction of chlorine with natural humic acids. MX is found in chlorinated drinking water all over the world and is an environmental carcinogen that is known to cause several types of cancer in rats when present in large enough Number: In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level.

As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens, although not always necessarily so. All mutagens have characteristic mutational signatures with some chemicals becoming. Hereis the first historical and sociological account of the formation of an interdisciplinary science known as genetic toxicology, and of the scientists’ social movement that created it.

After research geneticists discovered that synthetic chemicals were capable of changing the genetic structure of living organisms, scientists began to explore how these chemicals affected gene structure and Cited by: Mutagen X (MX), or 3-chloro (dichloromethyl)hydroxy-5 H -furanone, is a byproduct of the disinfection of water by chlorination.

MX is produced by reaction of chlorine with natural humic acid s. MX is found in chlorinated drinking water all over the world and is an environmental carcinogen that is known to cause several types.

formation of disinfection byproducts (DBPs), which can be cytotoxic, genotoxic, mutagenic, and developmentally toxic. Although > DBPs have been identified in drinking water, > 50% of the total organic halogen resulting from water chlorination and chloramination remains unknown.1 More-over, only approximately DBPs have undergone system-Author: Huiyu Dong, Huiyu Dong, Amy A.

Cuthbertson, Amy A. Cuthbertson, Susan D. Richardson. This is a comprehensive examination of the chemistry, environmental impact, and health effects of water chlorination as practiced in the areas of water treatment, wastewater treatment, wastewater disinfection, and cooling water use.

It is the peer-reviewed proceedings of the Sixth Conference on Water Chlorination held in Oak Ridge, volume represents more than merely conference. 3-Chloro(chloromethyl)hydroxy-2(5H)-furanone (CMCF) is a strong direct acting bacterial mutagen found in chlorine-disinfected drinking water.

We studied the reaction of CMCF with 2-deoxyadenosine in buffered aqueous solutions and found that three main adducts were by: 6. Hemming and co-authors () identified and pdf 3-chloro(dichloromethyl)5-hydroxy-2(5H)-furanone (MX), one of the most potent bacterial mutagens that is the product of the reaction of chlorine with the organic material present in water.There is limited information on the prevalence of the potent mutagen 3-cbloro(dichloromethyl)5-hydroxy-2(5m)- furanone (MX) in U.S.

water supplies. We measured MX concentrations and mutagenic activity in tap water samples from 36 surface water systems throughout Massachusetts.Start studying Mutagens. Learn vocabulary, terms, and more with flashcards, games, and other study tools.